Essential Relief Additional Information

Reports:

Ingredient Supporting Studies:

  1. Mark A. Schumacher. "TRP Channels in Pain and Inflammation: Therapeutic Opportunities." Pain Pract. 2010 May-Jun; 10(3): 185--200. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112370/
  2. Story GM, Crus-Orengo L. "Feel the burn". American Scientist 95 (4): 326--333. http://www.americanscientist.org/issues/feature/2007/4/feel-the-burn/99999
  3. https://en.wikipedia.org/wiki/The_Corsican_Brothers
  4. Nicoletta Galeottia, Lorenzo Di Cesare Mannellia, et al. "Menthol: a natural analgesic compound". Neuroscience Letters 322 (3): 145--148. http://www.sciencedirect.com/science/article/pii/S0304394001025277
  5. Lau, Benjamin K.; Karim, Shafinaz; Goodchild, Ann K.; Vaughan, Christopher W.; Drew, Geoffrey M. (2014-06-01). "Menthol enhances phasic and tonic GABAA receptor-mediated currents in midbrain periaqueductal grey neurons". British Journal of Pharmacology 171 (11): 2803--2813. http://www.ncbi.nlm.nih.gov/pubmed/24460753
  6. Freires IA, Denny C, Benso B, de Alencar SM, Rosalen PL. "Antibacterial Activity of Essential Oils and Their Isolated Constituents against Cariogenic Bacteria: A Systematic Review". Molecules 20 (4): 7329--7358. http://www.mdpi.com/1420-3049/20/4/7329/htm
  7. Olajide OA. "Inhibitory effects of St. John's Wort on inflammation: ignored potential of a popular herb." J Diet Suppl. 2009;6(1):28-32. http://www.ncbi.nlm.nih.gov/pubmed/22435352
  8. Sánchez-Mateo CC, Bonkanka CX, Hernández-Pérez M, Rabanal RM. "Evaluation of the analgesic and topical anti-inflammatory effects of Hypericum reflexum L. fil." J Ethnopharmacol. 2006 Aug 11;107(1):1-6. http://www.ncbi.nlm.nih.gov/pubmed/16549285
  9. Samadi S, Khadivzadeh T, Emami A, Moosavi, et al. "The effect of Hypericum perforatum on the wound healing and scar of cesarean." J Altern Complement Med. 2010 Jan;16(1):113-7. http://www.ncbi.nlm.nih.gov/pubmed/20064022
  10. Soheila Yadollah-Damavandi, Mehdi Chavoshi-Nejad, Ehsan Jangholi, et al. "Topical Hypericum perforatum Improves Tissue Regeneration in Full-Thickness Excisional Wounds in Diabetic Rat Model." Evid Based Complement Alternat Med. 2015; 2015: 245328. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568368/
  11. Simsek G, Sari E, Kilic R, Bayar Muluk N. "Topical Application of Arnica and Mucopolysaccharide Polysulfate Attenuates Periorbital Edema and Ecchymosis in Open Rhinoplasty: A Randomized Controlled Clinical Study." Plast Reconstr Surg. 2016 Mar;137(3):530e-5e. http://www.ncbi.nlm.nih.gov/pubmed/26910697
  12. Totonchi A, Guyuron B. "A randomized, controlled comparison between arnica and steroids in the management of postrhinoplasty ecchymosis and edema." Plast Reconstr Surg. 2007 Jul;120(1):271-4. http://www.ncbi.nlm.nih.gov/pubmed/17572575
  13. Kang JY, Tran KD, Seiff SR, Mack WP, Lee WW. "Assessing the Effectiveness of Arnica montana and Rhododendron tomentosum (Ledum palustre) in the Reduction of Ecchymosis and Edema After Oculofacial Surgery: Preliminary Results." Ophthal Plast Reconstr Surg. 2016 Feb 9. http://www.ncbi.nlm.nih.gov/pubmed/26863038
  14. Preethi KC, Kuttan G, Kuttan R. "Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action." Indian J Exp Biol. 2009 Feb;47(2):113-20. http://www.ncbi.nlm.nih.gov/pubmed/19374166
  15. Pommier P, Gomez F, Sunyach MP, et al. "Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer." J Clin Oncol. 2004 Apr 15;22(8):1447-53. http://jco.ascopubs.org/content/22/8/1447.long
  16. Tanideh N, Tavakoli P, Saghiri MA, et al. "Healing acceleration in hamsters of oral mucositis induced by 5-fluorouracil with topical Calendula officinalis." Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Mar;115(3):332-8. http://www.ncbi.nlm.nih.gov/pubmed/23182376
  17. Bashir S, Janbaz KH, Jabeen Q, Gilani AH. "Studies on spasmogenic and spasmolytic activities of Calendula officinalis flowers." Phytother Res. 2006 Oct;20(10):906-10. http://www.ncbi.nlm.nih.gov/pubmed/16906636
  18. Kim SO, Kundu JK, Shin YK, et al. "[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin." Oncogene. 2005 Apr 7;24(15):2558-67. http://www.ncbi.nlm.nih.gov/pubmed/15735738
  19. Pan MH, Hsieh MC, Hsu PC, et al. "6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages." Mol Nutr Food Res. 2008 Dec;52(12):1467-77. http://www.ncbi.nlm.nih.gov/pubmed/18683823
  20. Nakhostic-Roohi B, Barmaki S, Khoshkhahesh F, Bohlooli S. "Effects of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men". Journal of Pharmacy and Pharmacology. Volume 63, Issue 10,  pages 1290--1294, October 2011. http://onlinelibrary.wiley.com/doi/10.1111/j.2042-7158.2011.01314.x/abstract
  21. Barmaki, S; Bohlooli, S; Khoshkhahesh, F; Nakhostin-Roohi, B. "Effect of methylsulfonylmethane supplementation on exercise-induced muscle damage and total antioxidant capacity". J Sports Med Phys Fitness. 2012 Apr;52(2):170-4. http://www.ncbi.nlm.nih.gov/pubmed/22525653
  22. Thomas A Pagonis, Panagiotis A Givissis, Aristidis C Kritis, Anastasios C Christodoulou. "The Effect of Methylsulfonylmethane on Osteoarthritic Large Joints and Mobility." International Journal of Orthopedics. Vol 1, No 1 (2014). http://www.ghrnet.org/index.php/ijo/article/view/745/862
  23. Kim YH, Kim DH, Lim H, Baek DY, et al. "The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages." Biol Pharm Bull. 2009 Apr;32(4):651-6. https://www.jstage.jst.go.jp/article/bpb/32/4/32_4_651/_pdf
  24. Zhang M, Wong IG, Gin JB, Ansari NH. "Assessment of methylsulfonylmethane as a permeability enhancer for regional EDTA chelation therapy." Drug Deliv. 2009 Jul;16(5):243-8. http://www.ncbi.nlm.nih.gov/pubmed/19538004
  25. Tanen DA, Danish DC, Reardon JM, et al. " Comparison of oral aspirin versus topical applied methyl salicylate for platelet inhibition." Ann Pharmacother. 2008 Oct;42(10):1396-401. http://www.ncbi.nlm.nih.gov/pubmed/18698012
  26. Higashi Y, Kiuchi T, Furuta K. "Efficacy and safety profile of a topical methyl salicylate and menthol patch in adult patients with mild to moderate muscle strain: a randomized, double-blind, parallel-group, placebo-controlled, multicenter study." Clin Ther. 2010 Jan;32(1):34-43. http://www.ncbi.nlm.nih.gov/pubmed/20171409
  27. Jeengar MK, Kumar PS, Thummuri D, et al. "Review on emu products for use as complementary and alternative medicine." Nutrition. 2015 Jan;31(1):21-7. http://www.ncbi.nlm.nih.gov/pubmed/25441585
  28. Qiu XW, Wang JH, Fang XW, et al. "[Anti-inflammatory activity and healing-promoting effects of topical application of emu oil on wound in scalded rats]." Di Yi Jun Yi Da Xue Xue Bao. 2005 Apr;25(4):407-10. http://www.j-smu.com/pdf2/200504/200504407.pdf
  29. Akram M1, Naqvi SB, Khan A. "Design and development of insulin emulgel formulation for transdermal drug delivery and its evaluation." Pak J Pharm Sci. 2013 Mar;26(2):323-32. http://www.ncbi.nlm.nih.gov/pubmed/23455203
  30. Khodabakhsh P, Shafaroodi H, Asgarpanah J. "Analgesic and anti-inflammatory activities of Citrus aurantium L. blossoms essential oil (neroli): involvement of the nitric oxide/cyclic-guanosine monophosphate pathway." J Nat Med. 2015 Jul;69(3):324-31. http://www.ncbi.nlm.nih.gov/pubmed/25762161
  31. Sadraei H, Asghari G, Kasiri F. "Comparison of antispasmodic effects of Dracocephalum kotschyi essential oil, limonene and a-terpineol." Res Pharm Sci. 2015 Mar-Apr;10(2):109-16. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584449/
  32. Bharti Sapra, Subheet Jain, and A. K. Tiwary. "Percutaneous Permeation Enhancement by Terpenes: Mechanistic View." AAPS J. 2008 Mar; 10(1): 120--132. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751457/
  33. Diez I, Peraire C, Obach R, Domenech J. "Influence of d-limonene on the transdermal penetration of felodipine." Eur J Drug Metab Pharmacokinet. 1998 Jan-Mar;23(1):7-12. http://www.ncbi.nlm.nih.gov/pubmed/9625266
  34. Krishnaiah YS, Chandrasekhar DV, Rama B, Jayaram B, et al. "In vivo evaluation of limonene-based transdermal therapeutic system of nicorandil in healthy human volunteers." Skin Pharmacol Physiol. 2005 Nov-Dec;18(6):263-72. http://www.ncbi.nlm.nih.gov/pubmed/16113596
  35. http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/5164416
  36. Beilke, M; Collins-Lech, C; Sohnle, P (1987). "Effects of dimethyl sulfoxide on the oxidative function of human neutrophils". J Lab Clin Med. 1987 Jul;110(1):91-6. http://www.ncbi.nlm.nih.gov/pubmed/3598341
  37. H. Harry Szmant. "PHYSICAL PROPERTIES OF DIMETHYL SULFOXIDE AND ITS FUNCTION IN BIOLOGICAL SYSTEMS." DMSO Information Center. (6 Mar 2016.) http://www.dmso.org/articles/information/szmant.html
  38. Stanley W. Jacob. "Current Status of DIMETHYL SULFOXIDE (DMSO)." DMSO Information Center. March 2002. (6 Mar 2016.) http://www.dmso.org/articles/information/jacob.htm
  39. Marren K. "Dimethyl sulfoxide: an effective penetration enhancer for topical administration of NSAIDs." Phys Sportsmed. 2011 Sep;39(3):75-82. http://www.ncbi.nlm.nih.gov/pubmed/22030943
  40. Gelmini F, Ruscica M, Macchi C, et al. "Unsaponifiable Fraction of Unripe Fruits of Olea europaea: An Interesting Source of Anti-inflammatory Constituents." Planta Med. 2016 Feb;82(3):273-8. http://www.ncbi.nlm.nih.gov/pubmed/26544118
  41. Viljoen JM, Cowley A, du Preez J, Gerber M, du Plessis J. "Penetration enhancing effects of selected natural oils utilized in topical dosage forms." Drug Dev Ind Pharm. 2015;41(12):2045-54. http://www.ncbi.nlm.nih.gov/pubmed/26161938
  42. Hussain A, Khan GM, Jan SU, et al. "Effect of olive oil on transdermal penetration of flurbiprofen from topical gel as enhancer." Pak J Pharm Sci. 2012 Apr;25(2):365-9. http://www.ncbi.nlm.nih.gov/pubmed/22459463
  43. Pawan Kumar, Shailendra Kumar Singh, Dina Nath Mishra, and Priti Girotra. "Enhancement of ketorolac tromethamine permeability through rat skin using penetration enhancers: An ex-vivo study." Int J Pharm Investig. 2015 Jul-Sep; 5(3): 142--146. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522863/
  44. Zhang CF, Yang ZL, Luo JB. "[Effects of D-limonene and L-limonene on transdermal absorption of ligustrazine hydrochloride]." Yao Xue Xue Bao. 2006 Aug;41(8):772-7. http://www.ncbi.nlm.nih.gov/pubmed/17039786