Immunify Additional Information

Reports: 

Ingredient Supporting Studies:

  1. "Influenza: Fact Sheet No 211." WHO. March 2003. (Accessed 10 Oct 2014.) http://www.who.int/mediacentre/factsheets/2003/fs211/en/
  2. ristina Duda, "Flu Deaths Per Year." about health. 27 Jun 2014. (Accessed 10 Oct 2014.) http://coldflu.about.com/od/flu/qt/fludeathsperyear.htm
  3. Stoll, A., A. Renz & A. Brack. "Antibacterial substances II. Isolation and constitution of echinacoside, a glycoside from the roots of echinacea augustifolia." Helvetic Chimica Acta, 33, 1877-1893, 1950.
  4. rinda D, Diederich J, Wacker A. "Antiviral activity of components of Echinacea purpurea." Arzneimittelforschung. 1973 Aug;23(8):1119-20. http://www.ncbi.nlm.nih.gov/pubmed/4358341
  5. Barrett B. "Medicinal properties of Echinacea: A critical review." Phytomedecine, 2003, vol. 10, no1, pp. 66-86 [21 page(s). http://www.ncbi.nlm.nih.gov/pubmed?term=12622467
  6. Wagner H, Proksch A. "An immunostimulating active constituent from Echinacea purpurea." Z Phytother 1981;2:166-171.
  7. Bruce Barrett, Roger Brown, Dave Rakel, Marlon Mundt, et al. "Echinacea for Treating the Common Cold - A Randomized Trial." Annals of Internal Medicine. December 21, 2010 vol. 153 no. 12 769-777. http://www.annals.org/content/153/12/769.abstract
  8. Shah SA1, Sander S, White CM, Rinaldi M, Coleman CI. "Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis." Lancet Infect Dis. 2007 Jul;7(7):473-80. http://www.ncbi.nlm.nih.gov/pubmed/17597571
  9. Souza MA, Johann S, Lima LA, Campos FF, Mendes IC, et al. "The antimicrobial activity of lapachol and its thiosemicarbazone and semicarbazone derivatives." Mem Inst Oswaldo Cruz. 2013 May;108(3). pii: S0074-02762013000300342. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005582/
  10. Martino T, Magalhães FC, Justo GA, Coelho MG, et al. "The pterocarpanquinone LQB-118 inhibits tumor cell proliferation by downregulation of c-Myc and cyclins D1 and B1 mRNA and upregulation of p21 cell cycle inhibitor expression." Bioorg Med Chem. 2014 Jun 15;22(12):3115-22. http://www.ncbi.nlm.nih.gov/pubmed/24794748
  11. Sacau EP1, Estévez-Braun A, Ravelo AG, Ferro EA, et al. "Inhibitory effects of lapachol derivatives on epstein-barr virus activation." Bioorg Med Chem. 2003 Feb 20;11(4):483-8. http://www.ncbi.nlm.nih.gov/pubmed/12538012
  12. Pereira EM1, Machado Tde B, Leal IC, Jesus DM, Damaso CR, Pinto AV, et al. "Tabebuia avellanedae naphthoquinones: activity against methicillin-resistant staphylococcal strains, cytotoxic activity and in vivo dermal irritability analysis." Ann Clin Microbiol Antimicrob. 2006 Mar 22;5:5. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435768/
  13. Tandon VK, Singh RV, Yadav DB. "Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents." Bioorg Med Chem Lett. 2004 Jun 7;14(11):2901-4. http://www.ncbi.nlm.nih.gov/pubmed/15125956
  14. SOUZA, Nicolli Bellotti de et al. "Blood shizonticidal activities of phenazines and naphthoquinoidal compounds against Plasmodium falciparum in vitro and in mice malaria studies." Mem. Inst. Oswaldo Cruz [online]. 2014, vol.109, n.5 [cited  2014-10-08], pp. 546-552. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014005030603&lng=en&nrm=iso&tlng=en
  15. T Watanabe, M Watanabe, Y Watanabe, C Hotta. "Effects of oral administration of Pfaffia paniculata (Brazilian ginseng) on incidence of spontaneous leukemia in AKR/J mice." Cancer Detect Prev. 2000;24(2):173-8. http://www.ncbi.nlm.nih.gov/pubmed/10917139
  16. Watanabe T1, Watanabe M, Watanabe Y, Hotta C. "Effects of oral administration of Pfaffia paniculata (Brazilian ginseng) on incidence of spontaneous leukemia in AKR/J mice." Cancer Detect Prev. 2000;24(2):173-8. http://www.ncbi.nlm.nih.gov/pubmed/10917139
  17. Kaplan BJ1, Parish WW, Andrus GM, Simpson JS, Field CJ. "Germane facts about germanium sesquioxide: I. Chemistry and anticancer properties." J Altern Complement Med. 2004 Apr;10(2):337-44. http://www.ncbi.nlm.nih.gov/pubmed/15165414
  18. Stephen A. Levine, Ph.D. "Organic Germanium A Novel Dramatic Immunostimulant." Orthomolecular.org, (Accessed 27 Aug 2011) http://orthomolecular.org/library/jom/1987/pdf/1987-v02n02-p083.pdf
  19. Auyeung KK, Mok NL, Wong CM, Cho CH, Ko JK. "Astragalus saponins modulate mTOR and ERK signaling to promote apoptosis through the extrinsic pathway in HT-29 colon cancer cells." Int J Mol Med. 2010 Sep;26(3):341-9. http://www.ncbi.nlm.nih.gov/pubmed/20664949
  20. Liu QY, Yao YM. "The regulatory effect and mechanism of Astragalus polysaccharides on CD11c(high)CD45RB(low) dendritic cell." Zhonghua Shao Shang Za Zhi. 2011 Apr;27(2):95-9. http://www.ncbi.nlm.nih.gov/pubmed/21651844
  21. Cho WC1, Leung KN. "In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus." J Ethnopharmacol. 2007 Aug 15;113(1):132-41. http://www.ncbi.nlm.nih.gov/pubmed/17611061
  22. Lee JS, Hong EK. "Immunostimulating activity of the polysaccharides isolated from Cordyceps militaris." Int Immunopharmacol. 2011 Sep;11(9):1226-33. Epub 2011 Apr 14. http://www.ncbi.nlm.nih.gov/pubmed/21497206
  23. Jeong JW, Jin CY, Park C, Hong SH, Kim GY, Jeong YK, Lee JD, Yoo YH, Choi YH. "Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells." Toxicol In Vitro. 2011 Jun;25(4):817-24. Epub 2011 Feb 15. http://www.ncbi.nlm.nih.gov/pubmed/21310227
  24. Xiong Y1, Zhang S, Xu L, Song B, Huang G, Lu J, Guan S. "Suppression of T-cell activation in vitro and in vivo by cordycepin from Cordyceps militaris." J Surg Res. 2013 Dec;185(2):912-22. http://www.ncbi.nlm.nih.gov/pubmed/23927879
  25. Kumar R1, Negi PS, Singh B, Ilavazhagan G, Bhargava K, Sethy NK. "Cordyceps sinensis promotes exercise endurance capacity of rats by activating skeletal muscle metabolic regulators." J Ethnopharmacol. 2011 Jun 14;136(1):260-6. http://www.ncbi.nlm.nih.gov/pubmed/21549819
  26. Xu Z, Chen X, Zhong Z, Chen L, Wang Y. "Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities." Am J Chin Med. 2011;39(1):15-27. http://www.ncbi.nlm.nih.gov/pubmed/21213395
  27. Watanabe K, Shuto T, Sato M, Onuki K, Mizunoe S, Suzuki S, et al. "Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFa induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK." Biochem Biophys Res Commun. 2011 Apr 29;408(1):18-24. Epub 2011 Mar 29. http://www.ncbi.nlm.nih.gov/pubmed/21453678
  28. Shi Y1, Cai D, Wang X, Liu X. "Immunomodulatory effect of ganoderma lucidum polysaccharides (GLP) on long-term heavy-load exercising mice." Int J Vitam Nutr Res. 2012 Dec;82(6):383-90. http://www.ncbi.nlm.nih.gov/pubmed/23823923
  29. Hiroaki Nanba, Ph.D. "Maitake D-fraction: Healing and Preventive Potential for Cancer." The Journal of Orthomolecular Medicine Vol. 12, 1st Quarter 1997. http://orthomolecular.org/library/jom/1997/articles/1997-v12n01-p043.shtml
  30. Ishikawa, K. "Anti-HIV Activity in Cytopathic Effect of Proteoglucan Extracted from Maitake Mushroom," National Institute of Health, Jan 23, 1991
  31. Mayell M. "Maitake extracts and their therapeutic potential." Altern Med Rev. 2001 Feb;6(1):48-60. http://www.altmedrev.com/publications/6/1/48.pdf
  32. Wang Y1, Fang J, Ni X, Li J, Liu Q, Dong Q, Duan J, Ding K. "Inducement of cytokine release by GFPBW2, a novel polysaccharide from fruit bodies of Grifola frondosa , through dectin-1 in macrophages." J Agric Food Chem. 2013 Nov 27;61(47):11400-9. http://www.ncbi.nlm.nih.gov/pubmed/24229406
  33. Ito K, Masuda Y, Yamasaki Y, Yokota Y, Nanba H. "Maitake beta-glucan enhances granulopoiesis and mobilization of granulocytes by increasing G-CSF production and modulating CXCR4/SDF-1 expression." Int Immunopharmacol. 2009 Sep;9(10):1189-96. Epub 2009 Jun 30. http://www.ncbi.nlm.nih.gov/pubmed/19573626
  34. Kodama N, Mizuno S, Nanba H, Saito N. "Potential antitumor activity of a low-molecular-weight protein fraction from Grifola frondosa through enhancement of cytokine production." J Med Food. 2010 Feb;13(1):20-30. http://www.ncbi.nlm.nih.gov/pubmed/20136432
  35. Masuda Y1, Inoue M, Miyata A, Mizuno S, Nanba H. "Maitake beta-glucan enhances therapeutic effect and reduces myelosupression and nephrotoxicity of cisplatin in mice." Int Immunopharmacol. 2009 May;9(5):620-6. http://www.ncbi.nlm.nih.gov/pubmed/19249389
  36. eta Glucan Reasearch. http://www.betaglucan.org/
  37. AHCC Published Research. Accessed 28 Aug 2011. http://www.ahccpublishedresearch.com/default.htm
  38. Lee JK, Lee MK, Yun YP, Kim Y, Kim JS, Kim YS, Kim K, Han SS, Lee CK. "Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells." Int Immunopharmacol. 2001 Jul;1(7):1275-84. http://www.ncbi.nlm.nih.gov/pubmed?term=11460308
  39. Sierra-García GD, Castro-Ríos R, González-Horta A, Lara-Arias J, Chávez-Montes A. "Acemannan, an extracted polysaccharide from Aloe vera: A literature review." Nat Prod Commun. 2014 Aug;9(8):1217-21. http://www.ncbi.nlm.nih.gov/pubmed/25233608
  40. Ngwenya BZ, Foster DM. "Enhancement of antibody production by lysophosphatidylcholine and alkylglycerol." Proc Soc Exp Biol Med. 1991 Jan;196(1):69-75. http://www.ncbi.nlm.nih.gov/pubmed/1984244
  41. "Clinical Tests: Preventing Colds with APS45-10 Colostrum." Paper presented at Annual Meeting of Japanese Society of Clinical Nutrition 2007, The 13th Symposium of Adult Disease Countermeasure Society 2008, The 14th Symposium of Adult Disease Countermeasure Society 2009 and Annual Meeting of Japanese Dairy Science Association 2009. http://www.apsbiogroup.com/colostrum/references/Preventing_Colds.pdf
  42. Redwan EM1, Uversky VN, El-Fakharany EM, Al-Mehdar H. "Potential lactoferrin activity against pathogenic viruses." C R Biol. 2014 Oct;337(10):581-95. http://www.ncbi.nlm.nih.gov/pubmed/25282173
  43. Kariya C1, Leitner H, Min E, van Heeckeren C, van Heeckeren A, Day BJ. "A role for CFTR in the elevation of glutathione levels in the lung by oral glutathione administration." Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1590-7. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983954/
  44. Shaneyfelt ME, Burke AD, Graff JW, Jutila MA, Hardy ME. "Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay." Virol J. 2006 Sep 1;3:68. http://www.ncbi.nlm.nih.gov/pubmed/16948846
  45. Shibata MA, Iinuma M, Morimoto J, Kurose H, Akamatsu K, Okuno Y, Akao Y, Otsuki Y. "a-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation." BMC Med. 2011 Jun 3;9:69. http://www.ncbi.nlm.nih.gov/pubmed/21639868
  46. Hemilä H, Chalker E. "Vitamin C for preventing and treating the common cold." Cochrane Summaries. 31 May 2013. (Accessed 13 Oct 2014.) http://summaries.cochrane.org/CD000980/ARI_vitamin-c-for-preventing-and-treating-the-common-cold
  47. urata A, Oyadomari R, Ohashi T, Kitagawa K. "Mechanism of inactivation of bacteriophage deltaA containing single-stranded DNA by ascorbic acid." J Nutr Sci Vitaminol (Tokyo). 21:261-269. http://www.ncbi.nlm.nih.gov/pubmed/1214179
  48. Harakeh S, Jariwalla RJ, Pauling L. "Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells." Proc Natl Acad Sci USA. 87:7245-7249. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC54720/
  49. White LA, Freeman CY, Forrester BD, Chappell WA. "In vitro effect of ascorbic acid on infectivity of herpesviruses and paramyxoviruses." J Clin Microbiol. 24:527-531. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC268964/
  50. Furuya A, Uozaki M, Yamasaki H, Arakawa T, Arita M, Koyama AH. "Antiviral effects of ascorbic and dehydroascorbic acids in vitro." Int J Mol Med. 22:541-545. http://www.ncbi.nlm.nih.gov/pubmed/18813862
  51. Morrill K1, May K, Leek D, Langland N, Jeane LD, et al. "Spectrum of antimicrobial activity associated with ionic colloidal silver." J Altern Complement Med. 2013 Mar;19(3):224-31. http://www.ncbi.nlm.nih.gov/pubmed/23017226
  52. Nagai K, Suda T. "Immunoregulative effects of carnosine and beta-alanine. [Article in Japanese.] Nihon Seirigaku Zasshi. 1986;48(6):564-71. http://www.ncbi.nlm.nih.gov/pubmed/3097300
  53. Hunter KW, Jr. Gault RA, Stehouwer JS, Tam-Chang SW. "Synthesis of cetyl myristoleate and evaluation of its therapeutic efficacy in a murine model of collagen-induced arthritis." Pharmacol Res. 2003 Jan;47(1):43-7. http://www.ncbi.nlm.nih.gov/pubmed/12526860
  54. Waaga-Gasser AM. "Bovine colostrum--therapeutic synergism involving immunomodulation, nutritional supplementation and antibacterial action?" Int J Clin Pharmacol Ther. 2007 Apr;45(4):191-2. http://www.ncbi.nlm.nih.gov/pubmed/17474537
  55. Tae-Soo Lim, Keun Na, Eun-Mi Choi, Jae-Youn Chung and Jae-Kwan Hwang. "Immunomodulating Activities of Polysaccharides Isolated from Panax ginseng." Journal of Medicinal Food. April 2004, 7(1): 1-6. http://www.liebertonline.com/doi/abs/10.1089/109662004322984626
  56. William Chi Shing Choa, Kwok Nam Leungb. "In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus." Journal of Ethnopharmacology. Volume 113, Issue 1, 15 August 2007, Pages 132-141. http://www.sciencedirect.com/science/article/pii/S0378874107002668
  57. Arkady A. Semenov. "Natural Immuno-Modulators from Siberian Plants."  Irkutsk Institute of Chemistry, Siberian Division RAS, Irkutsk, 664033, Russia. http://www.nioch.nsc.ru/icnpas98/pdf/PDF_plenary/11.pdf
  58. Li HX, Sze SC, Tong Y, Ng TB. "Production of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes." J Ethnopharmacol. 2009 Jun 22;123(2):257-66. Epub 2009 Mar 20. http://www.ncbi.nlm.nih.gov/pubmed/19429370
  59. S. Antony, R. Kuttan, and G. Kuttan. "Immunomodulatory Activity of Curcumin." Immunological Investigations 1999, Vol. 28, No. 5-6 , Pages 291-303. http://informahealthcare.com/doi/abs/10.3109/08820139909062263