pHi-Zymes Additional Information

Reports:

Ingredient Supporting Studies:

  1. Hedstrom, L. (Dec 2002). "Serine protease mechanism and specificity." Chem Rev 102 (12): 4501--24. http://www.ncbi.nlm.nih.gov/pubmed/12475199
  2. Chapman HA, Riese RJ, Shi GP (1997). "Emerging roles for cysteine proteases in human biology." Annu. Rev. Physiol. 59: 63--88. http://www.ncbi.nlm.nih.gov/pubmed/9074757
  3. Arazi A1, Neumann AU. "Modeling immune complex-mediated autoimmune inflammation." J Theor Biol. 2010 Dec 7;267(3):426-36. http://www.ncbi.nlm.nih.gov/pubmed/20832412
  4. P O Cano, L M Jerry, J P Sladowski, and C K Osterland. "Circulating immune complexes in systemic lupus erythematosus." Clin Exp Immunol. Aug 1977; 29(2): 197--204. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1541106/pdf/clinexpimmunol00234-0013.pdf
  5. tauder G, Ransberger K, Streichhan P, Van Schaik W, Pollinger W. "The use of hydrolytic enzymes as adjuvant therapy in AIDS/ARC/LAS patients." Biomed Pharmacother. 1988;42(1):31-4. http://www.ncbi.nlm.nih.gov/pubmed/3408806
  6. Cecil Adams. "Is it aerodynamically impossible for bumblebees to fly?" The Straight Dope. May 4, 1990. (Accessed 24 Jun 2014.) http://www.straightdope.com/columns/read/1076/is-it-aerodynamically-impossible-for-bumblebees-to-fly
  7. Brad Rachman, "Unique Features and Application of Non-Animal Derived Enzymes." Clinical Nutrition Insights. 510 8/97 Vol. 5, No. 10. (Accessed 24 Jun 2014.) http://acudoc.com/Digestive%20Enzymes.PDF
  8. Laura P. Hale. "Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice." International Immunopharmacology. Volume 4, Issue 2, February 2004, Pages 255--264. http://www.sciencedirect.com/science/article/pii/S1567576903002972
  9. KOLAC C., STREICHHAN P., LEHR C.-M. "Oral bioavailability of proteolytic enzymes." European journal of pharmaceutics and biopharmaceutics. 1996, vol. 42, no4, pp. 222-232 (68 ref.) http://cat.inist.fr/?aModele=afficheN&cpsidt=3191444
  10. http://www.ncbi.nlm.nih.gov/pubmed/?term=nattokinase
  11. http://www.ncbi.nlm.nih.gov/pubmed/?term=bromelain+inflammation
  12. Stauder G. "Pharmacological effects of oral enzyme combinations." Cas Lek Cesk. 1995 Oct 4;134(19):620-4. http://www.ncbi.nlm.nih.gov/pubmed/7585874
  13. Nouza K. "Systemic enzyme therapy in diseases of the vascular system." Bratisl Lek Listy. 1995 Oct;96(10):566-9. http://www.ncbi.nlm.nih.gov/pubmed/8620329
  14. Beuth J. "Proteolytic enzyme therapy in evidence-based complementary oncology: fact or fiction?" Integr Cancer Ther. 2008 Dec;7(4):311-6. doi: 10.1177/1534735408327251. http://www.ncbi.nlm.nih.gov/pubmed/19116226
  15. Desser L, Rehberger A, Paukovits W. "Proteolytic enzymes and amylase induce cytokine production in human peripheral blood mononuclear cells in vitro." Cancer Biother 1994;9:253-63. http://www.ncbi.nlm.nih.gov/pubmed/7529614
  16. Fitzhugh DJ1, Shan S, Dewhirst MW, Hale LP. "Bromelain treatment decreases neutrophil migration to sites of inflammation." Clin Immunol. 2008 Jul;128(1):66-74. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516972/
  17. Tassman G, Zafran J, Zayon G. "A double-blind crossover study of a plant proteolytic enzyme in oral surgery." J Dent Med 1965;20:51--4. http://www.ncbi.nlm.nih.gov/pubmed/14282458
  18. Cirelli MG. "Treatment of inflammation and edema with bromelain." Delaware Med J 1962;34:159--67. http://www.ncbi.nlm.nih.gov/pubmed/13879585
  19. Brien S, Lewith G, Walker A, Hicks SM, Middleton D. "Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies." Evid Based Complement Alternat Med. 2004 Dec;1(3):251-257. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC538506/
  20. Akhtar NM1, Naseer R, Farooqi AZ, Aziz W, Nazir M. "Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study." Clin Rheumatol. 2004 Oct;23(5):410-5. http://www.ncbi.nlm.nih.gov/pubmed/15278753
  21. Heinicke R, van der Wal L, Yokoyama M. "Effect of bromelain (Ananase) on human platelet aggregation." Experientia 1972;28:844--5. http://www.ncbi.nlm.nih.gov/pubmed/4658882
  22. Juhasz B, Thirunavukkarasu M, Pant R, Zhan L, Penumathsa SV, et al. "Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium." Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1365-70. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581828/
  23. Rakhimov MR. "Anti-inflammatory activity of domestic papain]." Eksp Klin Farmakol. 2001 Jul-Aug;64(4):48-9. http://www.ncbi.nlm.nih.gov/pubmed/11589110
  24. Fujita M., Nomura K., Hong K., Ito Y., Asada A. and Nishimuro S.  "Purification and Characterization of a Strong Fibrinolytic Enzyme (Nattokinase) in the Vegetable Cheese Natto, a Popular Soybean Fermented Food in Japan." Biochemical and Biophysical Research Communications, Vol. 197, Issue 3, 30 December 1993, pp. 1340-1347. http://www.ncbi.nlm.nih.gov/pubmed/8280151
  25. Murakami K1, Yamanaka N, Ohnishi K, Fukayama M, Yoshino M. "Inhibition of angiotensin I converting enzyme by subtilisin NAT (nattokinase) in natto, a Japanese traditional fermented food." Food Funct. 2012 Jun;3(6):674-8. http://www.ncbi.nlm.nih.gov/pubmed/22453301
  26. Kim JY, Gum SN, Paik JK, et al. "Effects of nattokinase on blood pressure: a randomized, controlled trial." Hypertens Res. 2008;31(8):1583-1588. http://www.ncbi.nlm.nih.gov/pubmed/18971533
  27. Fossati A. "Anti-inflammatory effects of seaprose-S on various inflammation models."  Drugs Exp Clin Res. 1999;25(6):263-70. http://www.ncbi.nlm.nih.gov/pubmed/10713864
  28. Moretti M, Bertoli E, Bulgarelli S, Testoni C, et al. "Effects of seaprose on sputum biochemical components in chronic bronchitic patients: a double-blind study vs placebo." Int J Clin Pharmacol Res. 1993;13(5):275-80. http://www.ncbi.nlm.nih.gov/pubmed/8200722?dopt=Abstract
  29. raga PC, Rampoldi C et al "In vitro rheological assessment of mucolytic activity induced by seaprose." Pharmacol Res 1990;22(5):611-617. http://www.ncbi.nlm.nih.gov/pubmed/2277801
  30. Bracale G, Selvetella L. "Clinical study of the efficacy of and tolerance to seaprose S in inflammatory venous disease. Controlled study versus serratio-peptidase." Minerva Cardioangiol. 1996 Oct;44(10):515-24. http://www.ncbi.nlm.nih.gov/pubmed/9091835
  31. Bracale.
  32. Kuzan A1, Chwilkowska A, Kobielarz M, Pezowicz C, Gamian A. "Glycation of extracellular matrix proteins and its role in atherosclerosis. Postepy Hig Med Dosw (Online). 2012 Oct 29;66:804-9. http://www.ncbi.nlm.nih.gov/pubmed/23175335
  33. James Couch. "Rutin for Capillaries. USDA Yearbook of Agriculture. 1947 p711. http://naldc.nal.usda.gov/download/IND43893991/PDF
  34. Teresita Guardia, Alejandra Ester Rotelli, et al. "Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat." Il Farmaco Volume 56, Issue 9, 1 August 2001, Pages 683--687. http://www.sciencedirect.com/science/article/pii/S0014827X01011119
  35. Selloum L1, Bouriche H, Tigrine C, Boudoukha C. "Anti-inflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation." Exp Toxicol Pathol. 2003 Mar;54(4):313-8. http://www.ncbi.nlm.nih.gov/pubmed/12710715
  36. Drewa G, Schachtschabel DO, Palgan K, et al. "The influence of rutin on the weight, metastasis and melanin content of B16 melanotic melanoma in C57BL/6 mice." Neoplasma 1998;45:266-71. http://www.ncbi.nlm.nih.gov/pubmed/9890672
  37. Webster RP, Gawde MD, Bhattacharya RK. "Protective effect of rutin, a flavonol glycoside, on the carcinogen-induced DNA damage and repair enzymes in rats." Cancer Lett 1996;109:185-91. http://www.sciencedirect.com/science/article/pii/S0304383596044436
  38. Reema Jasuja, Freda H. Passam, Daniel R. Kennedy, Robert Flaumenhaft, et al. "Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents." J Clin Invest. 2012; 122(6):2104--2113. http://www.jci.org/articles/view/61228/version/2/pdf/render
  39. El-Akabawy G, El-Kholy W. "Neuroprotective effect of ginger in the brain of streptozotocin-induced diabetic rats." Ann Anat. 2014 May;196(2-3):119-28. http://www.ncbi.nlm.nih.gov/pubmed/24680376
  40. Yang M, Liu C, Jiang J, Zuo G, Lin X, et al. "Ginger extract diminishes chronic fructose consumption-induced kidney injury through suppression of renal overexpression of proinflammatory cytokines in rats." BMC Complement Altern Med. 2014 May 27;14(1):174. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047007/
  41. Moon M, Kim HG, Choi JG, Oh H, et al. "6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia." Biochem Biophys Res Commun. 2014 Jun 20;449(1):8-13. http://www.ncbi.nlm.nih.gov/pubmed/24796668
  42. Zeng GF1, Zhang ZY, Lu L, Xiao DQ, Zong SH, He JM. "Protective effects of ginger root extract on Alzheimer disease-induced behavioral dysfunction in rats." Rejuvenation Res. 2013 Apr;16(2):124-33. http://www.ncbi.nlm.nih.gov/pubmed/23374025
  43. Duskova M, Wald M. "Orally administered proteases in aesthetic surgery." Aesthetic Plast Surg. 1999 Jan;23(1):41-4. http://www.ncbi.nlm.nih.gov/pubmed/10022937